Hecder Lugo Perez, 22, died after being hit in the head by a projectile in the northwestern city of Valencia, sources at the Valles de San Diego medical clinic said.
Mass protests erupted on April 1 by demonstrators demanding elections to remove President Nicolas Maduro. Looting also broke out in Valencia.
Maduro is resisting pressure from the opposition, which blames him for an economic crisis that has led to food shortages.
City Mayor Enzo Scarano confirmed Perez's death.
Valencia has become one of the flashpoints of looting and clashes which have also seen violence at daily mass demos in the capital.
Reports said people in Valencia had begun hoarding basic foodstuffs and barricading housing developments to keep looters out.
The local chamber of commerce said at least 70 stores have been raided since Tuesday.
Maduro's opponents called for women to march on Saturday dressed in white, a traditional show of defiance against what they brand a repressive government.
The president says the crisis is a US-backed conspiracy.
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'Digital militia'
In a country where the government controls a broad network of newspapers and broadcasters, social media and new-wave journalism sites are key to following the political struggle between the socialist Maduro and his center-right opponents.
The sides in the conflict accuse each other of manipulating news online.
Maduro himself has created a "digital militia" to sign up citizens in the street for Twitter, Facebook and Instagram accounts and encourage them to circulate pro-government messages.
"It is a new front in the battle," says sociologist Maryclen Stelling.
"We have had the electoral one, the street one, the power conflict, the media front, and now we have the cross-media front."
Political judgment
When some of the fiercest clashes erupted on April 20, rumors spread online that Maduro had fled the country.
Videos spread purporting to show anti-aircraft searchlights being activated at the presidential palace.
It was later affirmed that the lights came from a theater show on a nearby square.
"There is a deliberate saturation of information so that you suspend your critical judgment," says Stelling.
"You do not know what is true and what is false. You decide depending on which political side you belong to."
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'Cyber terrorism'
Regular television channels have refrained from broadcasting images of the unrest in the streets even at the height of recent protests, screening light entertainment shows instead.
The Press Workers' Union denounced that as evidence of "a regime of censorship and self-censorship."
Reports of violence by security forces against protesters circulate unhindered online but have to compete with counter-claims by what Stelling calls "laboratories of war and cyber terrorism."
Social media are a gauge of the vitriol of the crisis.
Maduro's supporters have been using the hashtag #DerechaTerrorista -- "TerroristRightwing" -- against their opponents.
Supporters of the opposition overseas have been using #PrayforVenezuela.
In other messages, the tone is sharper, with leaders of the sides exchanging threats and insults.
Maduro retweeted a post likening the opposition to sewage, with a video showing protesters jumping into a river to escape tear gas.
His top opponent Henrique Capriles posted a video of Maduro dancing while protests raged.
"He who laughs last, lasts longest," Capriles wrote.
"Soon we who have been repressed will be laughing at you @nicolasmaduro and your corrupt allies."
